產品詳情介紹
玻連蛋白（Vitronectin，VTN），是一種多功能的糖蛋白，存在于血漿和細胞外基質中。玻連蛋白通過Arg-Gly-Asp (RGD) 序列介導，特定的細胞表面受體如整聯(lián)蛋白αVβ3和αVβ5結合，從而參與多種生理過程，在細胞的粘附、遷移、增殖和分化等過程中發(fā)揮重要作用[1-3]。它還可以與多種配體結合，如糖胺聚糖、膠原蛋白、纖溶酶原和尿激酶受體，并穩(wěn)定纖溶酶原激活抑制劑-1 的抑制構象[4]。玻連蛋白可促進內皮細胞貼附，伸展和增殖，促進多種正常細胞及癌細胞的分化，可用于細胞遷移實驗的研究[5]。VTN參與凝血、抑制膜攻擊復合物 (MAC) 的形成、細胞粘附和遷移、傷口愈合和組織重塑[6]。
[1] Suzuki S, Pierschbacher MD, Hayman EG, Nguyen K, Ohgren Y, Ruoslahti E. Domain structure of vitronectin. Alignment of active sites. J Biol Chem. 1984, 259(24):15307-15314.
[2] Hayman EG, Pierschbacher MD, Ohgren Y, Ruoslahti E. Serum spreading factor (vitronectin) is present at the cell surface and in tissues. Proc Natl Acad Sci USA. 1983, 80(13):4003-4007.
[3] Brown PJ, Juliano RL. Selective inhibition of fibronectin-mediated cell adhesion by monoclonal antibodies to a cell-surface glycoprotein. Science. 1985, 228(4706):1448-1451.
[4] Pytela R, Pierschbacher MD, Ruoslahti E. A 125/115-kDa cell surface receptor specific for vitronectin interacts with the arginine-glycine-aspartic acid adhesion sequence derived from fibronectin. Proc Natl Acad Sci USA. 1985, 82(17):5766-5770.
[5] Zou B, Yuan Q, et al. Combination of Fushengong decoction with Western medicine on patients with chronic renal failure: An observational study. Medicine (Baltimore). 2024, 103(15): e37473.
[6] Wijler LA, Viergever BJ, et al. Onward Spread from Liver Metastases Is a Major Cause of Multi-Organ Metastasis in a Mouse Model of Metastatic Colon Cancer. Cancers (Basel). 2024, 16(5):1073.
